B-type natriuretic peptide is a useful biomarker predicting disease severity in children with isolated bronchiolitis in the emergency department

Anil M., Goc Z., Avci R., Gokalp G., Bicilioglu Y., Kamit-Can F., ...Daha Fazla

TURKISH JOURNAL OF PEDIATRICS, cilt.59, sa.5, ss.561-569, 2017 (SCI-Expanded, Scopus, TRDizin) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 59 Sayı: 5
  • Basım Tarihi: 2017
  • Doi Numarası: 10.24953/turkjped.2017.05.009
  • Dergi Adı: TURKISH JOURNAL OF PEDIATRICS
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, TR DİZİN (ULAKBİM)
  • Sayfa Sayıları: ss.561-569
  • Manisa Celal Bayar Üniversitesi Adresli: Hayır

Özet

The aim of the study was to determine whether the B-type natriuretic peptide (BNP) plasma level predicted the severity of bronchiolitis without additional pathology in children admitted to an emergency department (ED). A total of 232 children (mean age: 7.7 +/- 1.2 months [range: 1-23 months]) presenting to ED with isolated bronchiolitis and 32 age- and gender-matched control subjects were included in the study. BNP levels differed significantly among the control (8.5 +/- 1.1 pg/ml) and mild (27.7 +/- 2.6 pg/ml), moderate (51.4 +/- 0.5 pg/ml), and severe (106.8 +/- 4.8 pg/ml) bronchiolitis groups (p<0.001). Clinical severity score (p<0.001; OR: 2.524; 95% CI: 1.826-3.487) and plasma BNP level (p<0.001; OR: 2.231; 95% CI: 1.583-3.242) were independent risk factors for hospitalization. The length of hospital stay was significantly correlated with BNP level (p<0.001; r: 0.698). In conclusion, the plasma BNP level may be a potent biomarker predicting disease severity in ED.