Akademik Veri Yönetim Sistemi
International Medical Journal, cilt.4, sa.4, ss.287-292, 1997 (Scopus)
The effect of ketotifen on ethanol-induced gastric lesions was examined in mice. For this purpose 36 mice were deprived of food for 20 hours. The mice were divided into four groups. Saline was given to the first group that is the control group by oesophageal intubation tube at first and then saline was given again after half an hour. Similarly, saline (0.15 ml) + 96% ethanol (0.15 ml), ketotifen (1mg/Kg) + 96% ethanol (0.15 ml) and ketotifen (1mg/Kg) + saline (0.15 ml) were given to the second, third and fourth groups respectively. Oral administration of 0.15 ml 96% ethanol produced hemorrhagic lesions in the gastric mucosa within 1 hour, and reduced the number of mucosal and submucosal mast cells of the stomach. Oral pretreatment with ketotifen (1 mg/Kg) strongly prevented both ethanol-induced gastric lesions and decreasing of mast cells in stomach. It was concluded that ketotifen prevents ethanol-induced gastric ulceration.