Research Information System
Turkish Journal of Medical Sciences, vol.29, no.6, pp.627-629, 1999 (Scopus, TRDizin)
Seven S-aroylmethyl N,N-disubstituted dithiocarbamate derivatives have been synthesized and their effects on oxotremorine induced tremor have been investigated on mice pretreated with the proparkinsonian drug haloperidol. While the compound 1f inhibited oxotremorine-induced tremors at doses of 50 mg/kg and 100 mg/kg levels, compounds 1a, 1c and 1e had this effect at the dose of 100 mg/kg. The compounds 1b, 1d and 1g had no effect on oxotremorine- induced tremors in mice. These results suggest that some of these derivatives have central antimuscarinic effects and antiparkinson activities.