Synthesis and characterization of chloralose-derived thiosemicarbazones and semicarbazones and investigation of their antimicrobial properties

Yetgin C. E., Oskay M., Ay K.

Journal of Carbohydrate Chemistry, cilt.33, sa.5, ss.238-251, 2014 (SCI-Expanded) identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 33 Sayı: 5
  • Basım Tarihi: 2014
  • Doi Numarası: 10.1080/07328303.2014.913060
  • Dergi Adı: Journal of Carbohydrate Chemistry
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.238-251
  • Anahtar Kelimeler: Thiosemicarbazone, Semicarbazone, Chloralose, Antimicrobial activity
  • Manisa Celal Bayar Üniversitesi Adresli: Evet

Özet

Thiosemicarbazones(7-10)/semicarbazones(11-14) were synthesized in good yields via the condensation of α-gluco-, β-gluco-, galacto-, manno- chloralose derived 1,4-furanodialdoses (1-4) with thiosemicarbazide(5)/ semicarbazide(6). The structures of all products were characterized by FTIR, NMR spectroscopic methods and elemental analysis. The compounds have been found to display moderate antimicrobial activity against Gram-positive, Gram-negative bacteria and antifungal activity against a Candida albicans. MIC values of the compounds range from 260 to 1510 g/mL. © 2014 Taylor & Francis Group, LLC.