Role of leukotrienes on coronary vasoconstriction in isolated hearts of arthritic rats: Effect of in vivo treatment with CI-986, a dual inhibitor of cyclooxygenase and lipoxygenase

Gök Ş., Ülker S., Hüseyinov A., Hatip F. B., Çinar M. G., Evinç A.

Pharmacology, cilt.60, sa.1, ss.41-46, 2000 (SCI-Expanded, Scopus) identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 60 Sayı: 1
  • Basım Tarihi: 2000
  • Doi Numarası: 10.1159/000028345
  • Dergi Adı: Pharmacology
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.41-46
  • Anahtar Kelimeler: Adjuvant-induced arthritis, Arachidonic acid, Cyclooxygenase, Isolated rat heart, Leukotrienes, Lipoxygenase
  • Manisa Celal Bayar Üniversitesi Adresli: Evet

Özet

In this study, coronary perfusion pressure and force of contraction were investigated in isolated hearts removed from arthritic rats by using the Langendorff method. A strong coronary vasoconstriction was determined in arthritic hearts which was associated with elevated levels of arachidonate 5-lipoxygenase (5-LOX) products, leukotriene B4 (LTB4) and LTC4 in coronary effluents. In vivo treatment with the dual inhibitor of cyclooxygenase (COX) and LOX, CI-986 (2 and 10 mg/kg/day) on days 14-26 following adjuvant injection, prevented the coronary vasoconstriction and the increased production of LTB4 and LTC4. These results suggest that the coronary vasoconstriction in the isolated arthritic hearts is associated with an increased activity of the LOX system and CI-986 could have a preventive effect on constriction of coronary arteries.