Effects of nitric oxide-vascular endothelial growth factor systems in chick embryo cerebral vasculogenesis and angiogenesis Civciv Embriyosunda Serebral Vaskülogenezis ve Anjiogenezis Üzerine Nitrik Oxid-Vasküler Endotelyal Growth Faktörün Etkileri

TEMİZ C., Arslan M., Sayın M., Vatansever S., Giray G., Var A.

Journal of Clinical and Analytical Medicine, vol.3, no.4, pp.393-397, 2012 (Scopus, TRDizin) identifier identifier

  • Publication Type: Article / Article
  • Volume: 3 Issue: 4
  • Publication Date: 2012
  • Doi Number: 10.4328/jcam.778
  • Journal Name: Journal of Clinical and Analytical Medicine
  • Journal Indexes: Scopus, TR DİZİN (ULAKBİM)
  • Page Numbers: pp.393-397
  • Keywords: Angiogenezis, Vasculogenesis, Nitric Oxide, Vascular Endothelial Growth Factor
  • Manisa Celal Bayar University Affiliated: Yes

Abstract

Aim: Studies have depicted that nitric oxide and vascular endothelial growth factor systems have important biological effects in the development of vasculogenesis and angiogenesis. Material and Method: In this study; specific pathogen free white Leghorin type fertilised eggs were used. Result: Three main subgroups were designed regarding time points of 48; 72 and 80 hours of incubation. In 48 hours old embryos anjioblasts were seen; but no mature endothelial structure was present. In 72 hours old embryos endothelial maturation began. In the 80 hours there was a high level of endothelial maturation. In all 48 hours groups; tissue nitrite-nitrate concentrations were high but in the 72 hours group these values were higher than in the first group. In the 80 hours group; concentrations were lower and were statistically significant when compared to the 48 and 72 hours groups. Discussion: NO seems to be effective in early phases of vasculogenesis and angiogenesis; but its effect decreases with time.