JNK/FOXO may be key mechanistic pathway for the hormetic anti-aging

Erol A.

Medical Hypotheses, cilt.68, sa.4, ss.923-924, 2007 (SCI-Expanded, Scopus) identifier identifier identifier

  • Yayın Türü: Makale / Kısa Makale
  • Cilt numarası: 68 Sayı: 4
  • Basım Tarihi: 2007
  • Doi Numarası: 10.1016/j.mehy.2006.09.022
  • Dergi Adı: Medical Hypotheses
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.923-924
  • Manisa Celal Bayar Üniversitesi Adresli: Evet

Özet

FOXO transcription factors and evolutionarily conserved c-jun N-terminal kinase (JNK) could hold the key to counteract hormetic anti-aging and common diseases. Hormesis is increasingly recognized as a mechanism underlying the beneficial anti-aging effects of certain genetic and environmental factors. Caloric restriction and exercise increase the resistance of organisms to stress and activate stress resistance pathways in cells in different tissues throughout the body by hormesis based mechanism. JNK triggers the relocalization of FOXO factors to the nucleus inducing the expression of FOXO dependent stress response and damage repairing genes. This adaptive response to stress stimuli may play an important role in regulating homeostasis at the organismal level and contribute to longevity.