Research Information System
INTERNATIONAL JOURNAL OF CLINICAL PRACTICE, vol.2026, no.1, pp.1-9, 2026 (SCI-Expanded, Scopus)
ABSTRACTIntroduction: Transperineal (TP) prostate biopsy ofers several advantages over transrectal (TR) prostate biopsy, includinga reduced risk of infection and improved accessibility to hard-to-reach areas of the prostate. This retrospective study aims to presentour clinical experience and compare the outcomes of TP and TR prostate biopsy methods.Materials and Methods: We retrospectively analyzed patients who underwent TP or TR prostate biopsy between January 2024and September 2024 at the Department of Urology, Manisa Celal Bayar University Hospital. A total of 40 patients underwent TPbiopsy, and 40 patients underwent TR biopsy. Data extracted included prostate-specifc antigen (PSA) levels, prostate size, ProstateImaging Reporting and Data System (PI-RADS) scores obtained from multiparametric magnetic resonance imaging (mpMRI), painscores, postprocedural complications (e.g., infection, lower urinary tract symptoms [LUTS], and hematuria), and pathologicaloutcomes such as overall cancer detection rates and the percentage of cancerous nuclei.Results: In the TP biopsy group, cancer was detected in 62% of patients, compared to 45% in the TR biopsy group. Concordancebetween MRI imaging fndings and pathology was observed in 57% of the TP group, whereas this rate was 40% in the TR group.Regarding complications, no infections were reported in the TP group, while hematuria occurred in 7% and LUTS in 17%. In the TRgroup, infection occurred in 7%, hematuria in 10%, and LUTS in 5% of patients. Pain scores during the procedure difered betweenthe groups. In the TP group, the highest pain score was 4, and the most commonly reported score was 2. During probe insertion, thepain score was most frequently 2, with a maximum of 4. In the TR group, the highest pain score during the procedure was 5, and themost common score was 3. During probe insertion, the most frequent score was 3, with a maximum score of 4.Conclusion: These fndings highlight the advantages of TP biopsy, including a higher diagnostic yield, lower complication rates, andbetter patient-reported satisfaction. Therefore, TP biopsy should be considered the primary method for prostate biopsies in clinical practice.